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Writer's pictureNatalie O Regan

Cannabis Use Leaves a Distinct Mark on DNA



New research reveals a potential link between high-potency cannabis and epigenetic changes. A new study published in Molecular Psychiatry has uncovered evidence suggesting that frequent use of high-potency cannabis can leave a lasting mark on our DNA. This is the first research to demonstrate the drug's potential to alter our genetic makeup.


The study, led by researchers at King's College London and the University of Exeter, analysed DNA samples from over 600 participants, including those with and without a history of psychosis. They found that those who regularly used high-potency cannabis, defined as having a THC content of 10% or more, exhibited distinct changes in their DNA. These changes were linked to genes related to energy production and the immune system.



This research offers valuable insights into the biological impact of cannabis use, particularly on mental health. It suggests that the drug can have long-term effects, even after it is no longer in the body. The study's authors believe that the DNA changes they identified could be used to predict who is at risk of developing mental health problems related to cannabis use. This could lead to more targeted prevention and treatment strategies.



Understanding the Implications

The findings of this study have significant implications for public health and policy. As the legalisation of cannabis continues to spread, it is essential to have a comprehensive understanding of its potential risks and benefits. This research provides valuable insights into the biological mechanisms through which cannabis can impact our health.



The Science Behind the Study

The study focused on DNA methylation, a chemical process that alters how genes are expressed. Both genetic factors and environmental factors, including substance use influence this process. By analysing DNA methylation patterns, researchers can gain insights into how lifestyle choices affect our genes.


The study found that frequent use of high-potency cannabis was associated with changes in genes related to mitochondrial function, which is essential for energy production, and immune function. These changes suggest that cannabis use can have a significant impact on our body's ability to produce energy and fight off infections.


Potential Health Risks

While the study did not definitively prove that cannabis use causes mental health problems, it does provide evidence that it can have a lasting impact on our biology. This raises concerns about the potential long-term health risks associated with frequent cannabis use, particularly high-potency strains.


This study provides compelling evidence that frequent use of high-potency cannabis can leave a lasting mark on our DNA. While more research is needed to fully understand the implications of these findings, the study highlights the importance of considering the potential long-term health risks associated with cannabis use. As the legalisation of cannabis continues to spread, it is essential to have a comprehensive understanding of its effects on our health and well-being.


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